mouse ERN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ern1.
shADV-258677
Ad-m-ERN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ern1 (endoplasmic reticulum (ER) to nucleus signalling 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9030414B18Rik; AI225830; C85377; Ire1a; Ire1alpha; Ire1p
Description (Vector)
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Gene ID
78943
Gene Name (Vector)
endoplasmic reticulum (ER) to nucleus signalling 1
Gene Symbol
Ern1
ORF Size (aa)
2934
ORF Size (bp)
2934 bp
RefSeq ID
NM_023913
RefSeq Synonyms
NM_023913, BC156947, BC156204,
Species
mouse
UniGene ID
Mm.340943
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.