human SAPS1 shRNA silencing Adenovirus

Name 
Ad-h-SAPS1-shRNA
Cat No 
shADV-222240
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PPP6R1.

shADV-222240
Ad-h-SAPS1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP6R1 (protein phosphatase 6 regulatory subunit 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
KIAA1115; PP6R1; SAP190; SAPS domain family member 1; SAPS domain family, member 1; SAPS1; serine/threonine-protein phosphatase 6 regulatory subunit 1
Description (eCommerce)
SAPS1 is a regulatory subunit of the PP6 phosphatase. There are 3 human SAPs (sit4-associated proteins), SAPS1, SAPS2, and SAPS3. The human SAPs are related to SAPs found in yeast that associate with the sit4 phosphatase which is the homolog of human PP6 phosphatase. In yeast sit4 and its associated SAPs are involved in a variety of processes which include transcription, translation, bud formation, glycogen metabolism, ion homeostasis, and telomere function. SAPS1 mRNA has been found to be overexpressed in hepatocellular carcinoma, metastatic liver tumors, and lymphoblastic leukemia.
Description (Vector)
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 (PubMed 16769727)).(supplied by OMIM, Nov 2010)
Gene ID
22870
Gene Name (eCommerce)
protein phosphatase 6 regulatory subunit 1
Gene Name (Vector)
protein phosphatase 6 regulatory subunit 1
Gene Symbol
PPP6R1
HGNC ID
HGNC:29195
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2646
ORF Size (bp)
2646 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 6 regulatory subunit 1
RefSeq ID
NM_014931
RefSeq Synonyms
NM_014931, BC094753,
Research Areas
Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
SAPS1 is a regulatory subunit of the PP6 phosphatase. There are 3 human SAPs (sit4-associated proteins), SAPS1, SAPS2, and SAPS3. The human SAPs are related to SAPs found in yeast that associate with the sit4 phosphatase which is the homolog of human PP6 phosphatase. In yeast sit4 and its associated SAPs are involved in a variety of processes which include transcription, translation, bud formation, glycogen metabolism, ion homeostasis, and telomere function. SAPS1 mRNA has been found to be overexpressed in hepatocellular carcinoma, metastatic liver tumors, and lymphoblastic leukemia.
UniGene ID
Hs.515610
UniProt ID (eCommerce)
Q9UPN7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.