human SAMHD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SAMHD1.
shADV-222231
Ad-h-SAMHD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CHBL2; DCIP; dendritic cell-derived IFNG-induced protein; deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; HDDC1; hSAMHD1; monocyte protein 5; MOP-5; SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1; SBBI88
Description (eCommerce)
SAM domain and HD domain-containing protein 1 (SAMHD1) is a putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. SAMHD1 may play a role in mediating proinflammatory responses to TNF-alpha signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y3Z3].
Description (Vector)
SAMHD1 may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Gene ID
25939
Gene Name (eCommerce)
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Gene Name (Vector)
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Gene Symbol
SAMHD1
HGNC ID
HGNC:15925
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1881
ORF Size (bp)
1881 bp
Protein Name (eCommerce)
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
RefSeq ID
NM_015474
RefSeq Synonyms
NM_015474, BC036450,
Research Areas
Host-Virus Interactions,Immunology,Innate Immunity,Kinase/Phosphatase,Response to Virus,RNA Binding,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
SAM domain and HD domain-containing protein 1 (SAMHD1) is a putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. SAMHD1 may play a role in mediating proinflammatory responses to TNF-alpha signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y3Z3].
UniGene ID
Hs.580681
UniProt ID (eCommerce)
Q9Y3Z3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.