human RRAGC shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RRAGC.
shADV-221991
Ad-h-RRAGC-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RRAGC (Ras related GTP binding C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; RAGC; ras-related GTP-binding protein C; TIB929
Description (eCommerce)
Ras-related GTP-binding protein C (RagC) has guanine nucleotide-binding activity but weak intrinsic GTPase activity. RagC is probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HB90].
Description (Vector)
RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.(supplied by OMIM, Apr 2004)
Gene ID
64121
Gene Name (eCommerce)
Ras related GTP binding C
Gene Name (Vector)
Ras related GTP binding C
Gene Symbol
RRAGC
HGNC ID
HGNC:19902
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
Protein Name (eCommerce)
Ras-related GTP-binding protein C
RefSeq ID
NM_022157
RefSeq Synonyms
NM_022157, NM_001271851, BC016668,
Research Areas
Apoptosis,Lysosome,mTOR Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Ras-related GTP-binding protein C (RagC) has guanine nucleotide-binding activity but weak intrinsic GTPase activity. RagC is probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HB90].
UniGene ID
Hs.532461
UniProt ID (eCommerce)
Q9HB90
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.