human RING1 shRNA silencing Adenovirus

Name 
Ad-h-RING1-shRNA
Cat No 
shADV-221246
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RING1.

shADV-221246
Ad-h-RING1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RING1 (ring finger protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase RING1; polycomb complex protein RING1; really interesting new gene 1 protein; RING finger protein 1; RING1A; RING-type E3 ubiquitin transferase RING1; RNF1
Description (eCommerce)
Ring finger protein 1 (RING1) belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. RING1 can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. RING1 interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It also interacts with the CBX4 protein via its glycine-rich C-terminal domain [taken from NCBI Entrez Gene (Gene ID: 6015)].
Description (Vector)
RING1 belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.
Gene ID
6015
Gene Name (eCommerce)
ring finger protein 1
Gene Name (Vector)
ring finger protein 1
Gene Symbol
RING1
HGNC ID
HGNC:10018
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1221
ORF Size (bp)
1221 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase RING1
RefSeq ID
NM_002931
RefSeq Synonyms
NM_002931, BC051866, BC002922,
Research Areas
Chromatin Remodeling,Complexome,Histone Modification,Notch Signaling,Polycomb Proteins,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology,transcription_translation,cell_biology,genetics,signal_transduction,developmental_biology,cell_biology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Ring finger protein 1 (RING1) belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. RING1 can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. RING1 interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It also interacts with the CBX4 protein via its glycine-rich C-terminal domain [taken from NCBI Entrez Gene (Gene ID: 6015)].
UniGene ID
Hs.631989
UniProt ID (eCommerce)
Q06587

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.