human RECQL shRNA silencing Adenovirus

Name
Ad-h-RECQL-shRNA

Cat No
shADV-220974

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human RECQL.

shADV-220974

Ad-h-RECQL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RECQL (RecQ like helicase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ATP-dependent DNA helicase Q1; DNA helicase, RecQ-like type 1; DNA-dependent ATPase Q1; RecQ helicase-like; RecQ protein-like (DNA helicase Q1-like); recQ protein-like 1; RecQ1; RECQL1

Description (eCommerce)

RecQ1 is a member of the RecQ family of DNA helicases that functions in DNA repair, recombination, and replication and is important to the maintenance of genomic stability.

Description (Vector)

RECQL is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described.

Gene ID

5965

Gene Name (eCommerce)

RecQ like helicase

Gene Name (Vector)

RecQ like helicase

Gene Symbol

RECQL

HGNC ID

HGNC:9948

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1950

ORF Size (bp)

1950 bp

Protein Name (eCommerce)

ATP-dependent DNA helicase Q1

RefSeq ID

NM_002907

RefSeq Synonyms

NM_032941, NM_002907, BC001052,

Research Areas

Cytoskeleton,DNA Damage/Repair,DNA Replication,Helicase Activity

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

RecQ1 is a member of the RecQ family of DNA helicases that functions in DNA repair, recombination, and replication and is important to the maintenance of genomic stability.

UniGene ID

Hs.235069

UniProt ID (eCommerce)

P46063

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.