human RCC2 shRNA silencing Adenovirus

Name 
Ad-h-RCC2-shRNA
Cat No 
shADV-220938
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RCC2.

shADV-220938
Ad-h-RCC2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RCC2 (regulator of chromosome condensation 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; protein RCC2; RCC1-like protein TD-60; TD-60; telophase disk protein of 60 kDa
Description (eCommerce)
RCC2 (regulator of chromosome condensation 2) is a member of the RCC1 family of guanine nucleotide exchange factors. RCC2 has been identified as part of the chromosomal passenger complex (CPC) which coordinates the chromosomal and cytoskeletal events of mitosis. Chromosomal passengers are proteins present in complexes with aurora B, inner centromeric protein (INCENP), survivin, and borealin. RCC2 has been demonstrated to be required for the recruitment of survivin and aurora B and is essential for proper chromosome segregation and the completion of cell cleavage. Loss of RCC2 inhibits spindle assembly, activates the spindle assembly checkpoint, and blocks cells in prometaphase.
Gene ID
55920
Gene Name (eCommerce)
regulator of chromosome condensation 2
Gene Name (Vector)
regulator of chromosome condensation 2
Gene Symbol
RCC2
HGNC ID
HGNC:30297
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1569
ORF Size (bp)
1569 bp
Protein Name (eCommerce)
Protein RCC2
RefSeq ID
NM_018715
RefSeq Synonyms
NM_018715, NM_001136204, BC053908, BC042141,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
RCC2 (regulator of chromosome condensation 2) is a member of the RCC1 family of guanine nucleotide exchange factors. RCC2 has been identified as part of the chromosomal passenger complex (CPC) which coordinates the chromosomal and cytoskeletal events of mitosis. Chromosomal passengers are proteins present in complexes with aurora B, inner centromeric protein (INCENP), survivin, and borealin. RCC2 has been demonstrated to be required for the recruitment of survivin and aurora B and is essential for proper chromosome segregation and the completion of cell cleavage. Loss of RCC2 inhibits spindle assembly, activates the spindle assembly checkpoint, and blocks cells in prometaphase.
UniGene ID
Hs.380857
UniProt ID (eCommerce)
Q9P258

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.