human RBBP8 shRNA silencing Adenovirus

Name 
Ad-h-RBBP8-shRNA
Cat No 
shADV-220834
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RBBP8.

shADV-220834
Ad-h-RBBP8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RBBP8 (RB binding protein 8, endonuclease). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
COM1; CTBP-interacting protein; CTIP; DNA endonuclease RBBP8; JWDS; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RIM; SAE2; SCKL2; sporulation in the absence of SPO11 protein 2 homolog
Description (eCommerce)
CtIP (CTBP interacting protein) was first identified as a protein that interacted with CTBP (C-terminus-binding protein of adenovirus E1A). CtIP has also been identified as a protein that interacts with the tumor suppressors pRb and BRCA1 and has been implicated as a tumor suppressor itself.
Description (Vector)
RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Gene ID
5932
Gene Name (eCommerce)
RB binding protein 8, endonuclease
Gene Name (Vector)
RB binding protein 8, endonuclease
Gene Symbol
RBBP8
HGNC ID
HGNC:9891
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2709
ORF Size (bp)
2709 bp
Protein Name (eCommerce)
DNA endonuclease RBBP8
RefSeq ID
NM_002894
RefSeq Synonyms
NM_203292, NM_203291, NM_002894, BC030590,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Homologous Recombination,Meiosis,Neurobiology,Notch Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,neurobiology,signal_transduction,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
CtIP (CTBP interacting protein) was first identified as a protein that interacted with CTBP (C-terminus-binding protein of adenovirus E1A). CtIP has also been identified as a protein that interacts with the tumor suppressors pRb and BRCA1 and has been implicated as a tumor suppressor itself.
UniGene ID
Hs.546282
UniProt ID (eCommerce)
Q99708

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.