human RBBP4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RBBP4.
shADV-220824
Ad-h-RBBP4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RBBP4 (RB binding protein 4, chromatin remodeling factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; chromatin assembly factor 1 subunit C; chromatin assembly factor I p48 subunit; chromatin assembly factor/CAF-1 p48 subunit; histone-binding protein RBBP4; lin-53; MSI1 protein homolog; nucleosome-remodeling factor subunit RBAP48; NURF55; RBAP48; RBBP-4; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48
Description (eCommerce)
RbBP4 is a member of the WD-repeat subfamily of proteins and is a component of multiple complexes involved in chromatin assembly, histone deacetylation, and transcriptional repression. RbBP4 has also been identified as a retinoblastoma (Rb) binding protein and plays a role in the repression of E2F-regulated genes in association with Rb and histone deacetylases.
Description (Vector)
RBBP4 encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
5928
Gene Name (eCommerce)
RB binding protein 4, chromatin remodeling factor
Gene Name (Vector)
RB binding protein 4, chromatin remodeling factor
Gene Symbol
RBBP4
HGNC ID
HGNC:9887
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1278
ORF Size (bp)
1278 bp
Protein Name (eCommerce)
Histone-binding protein RBBP4
RefSeq ID
NM_005610
RefSeq Synonyms
NM_005610, NM_001135256, NM_001135255, BC075836, BC053904, BC003092,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Complexome,DNA Replication,Epigenetic Regulation of Gene Expression,Hedgehog Signaling,Polycomb Proteins,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
RbBP4 is a member of the WD-repeat subfamily of proteins and is a component of multiple complexes involved in chromatin assembly, histone deacetylation, and transcriptional repression. RbBP4 has also been identified as a retinoblastoma (Rb) binding protein and plays a role in the repression of E2F-regulated genes in association with Rb and histone deacetylases.
UniGene ID
Hs.16003
UniProt ID (eCommerce)
Q09028
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.