human RASGRP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RASGRP1.
shADV-220778
Ad-h-RASGRP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RASGRP1 (RAS guanyl releasing protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V
Description (Vector)
RASGRP1 is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Gene ID
10125
Gene Name (Vector)
RAS guanyl releasing protein 1
Gene Symbol
RASGRP1
HGNC ID
HGNC:9878
ORF Size (aa)
2394
ORF Size (bp)
2394 bp
RefSeq ID
NM_005739
RefSeq Synonyms
NM_005739, NM_001306086, NM_001128602, BC109297, BC109296,
Species
human
UniGene ID
Hs.591127
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.