human RACGAP1 shRNA silencing Adenovirus

Name 
Ad-h-RACGAP1-shRNA
Cat No 
shADV-220630
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RACGAP1.

shADV-220630
Ad-h-RACGAP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RACGAP1 (Rac GTPase activating protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CYK4; HsCYK-4; ID-GAP; male germ cell RacGap; MgcRacGAP; protein CYK4 homolog; rac GTPase-activating protein 1
Description (eCommerce)
Male germ cell Rac GTPase-activating protein (MgcRacGAP) is essential for the early stages of embryogenesis and may play a role in the microtubule-dependent steps in cytokinesis. MgcRacGAP plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. It also is involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation [taken from the Universal Protein Resource (UniProt) www antibody.uniprot.org/uniprot/ Q9H0H5].
Description (Vector)
RACGAP1 belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
Gene ID
29127
Gene Name (eCommerce)
Rac GTPase activating protein 1
Gene Name (Vector)
Rac GTPase activating protein 1
Gene Symbol
RACGAP1
HGNC ID
HGNC:9804
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1899
ORF Size (bp)
1899 bp
Protein Name (eCommerce)
Rac GTPase-activating protein 1
RefSeq ID
NM_013277
RefSeq Synonyms
NM_013277, NM_001320007, NM_001320006, NM_001320005, NM_001320004, NM_001320003, NM_001320002, NM_001320001, NM_001320000, NM_001319999, NM_001126104, NM_001126103, BC032754,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Cytoskeleton,EGFR Signaling,Immunology,Neurobiology,Neurodevelopment,RAC1 Signaling,Signal Transduction,Spermatogenesis,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Male germ cell Rac GTPase-activating protein (MgcRacGAP) is essential for the early stages of embryogenesis and may play a role in the microtubule-dependent steps in cytokinesis. MgcRacGAP plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. It also is involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation [taken from the Universal Protein Resource (UniProt) www antibody.uniprot.org/uniprot/ Q9H0H5].
UniGene ID
Hs.505469
UniProt ID (eCommerce)
Q9H0H5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.