human PTPN3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PTPN3.
shADV-220323
Ad-h-PTPN3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPN3 (protein tyrosine phosphatase, non-receptor type 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cytoskeletal-associated protein tyrosine phosphatase; protein-tyrosine phosphatase H1; PTPH1; PTP-H1; tyrosine-protein phosphatase non-receptor type 3
Description (eCommerce)
PTPN3 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.PTPN3 contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. [taken from NCBI Entrez Gene (Gene ID: 5774)].
Description (Vector)
PTPN3 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5774
Gene Name (eCommerce)
protein tyrosine phosphatase, non-receptor type 3
Gene Name (Vector)
protein tyrosine phosphatase, non-receptor type 3
Gene Symbol
PTPN3
HGNC ID
HGNC:9655
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2742
ORF Size (bp)
2742 bp
Protein Name (eCommerce)
Tyrosine-protein phosphatase non-receptor type 3
RefSeq ID
NM_002829
RefSeq Synonyms
NM_002829, NM_001145372, NM_001145371, NM_001145370, NM_001145369, NM_001145368, BC143848, BC126117,
Research Areas
Cell Cycle,Cytoskeleton,Immunology,Kinase/Phosphatase,Phosphatase,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
PTPN3 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.PTPN3 contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. [taken from NCBI Entrez Gene (Gene ID: 5774)].
UniGene ID
Hs.436429
UniProt ID (eCommerce)
P26045
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.