human PTPN2 shRNA silencing Adenovirus

Name 
Ad-h-PTPN2-shRNA
Cat No 
shADV-220315
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PTPN2.

shADV-220315
Ad-h-PTPN2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPN2 (protein tyrosine phosphatase, non-receptor type 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PTN2; PTPT; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP; tyrosine-protein phosphatase non-receptor type 2
Description (eCommerce)
The gene PTPN2, also known as TCPTP or TCP-TP, encodes for the protein tyrosine phosphatase (PTP) family member, tyrosine-protein phosphatase non-receptor type 2. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN2 dephosphorylates both receptor and non-receptor protein tyrosine kinases. PTPN2/TCPTP negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis [taken from NCBI Entrez Gene (Gene ID: 5771) and UniProtKB (Entry: P17706)].
Description (Vector)
PTPN2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
Gene ID
5771
Gene Name (eCommerce)
protein tyrosine phosphatase, non-receptor type 2
Gene Name (Vector)
protein tyrosine phosphatase, non-receptor type 2
Gene Symbol
PTPN2
HGNC ID
HGNC:9650
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1062
ORF Size (bp)
1062 bp
Protein Name (eCommerce)
Tyrosine-protein phosphatase non-receptor type 2
RefSeq ID
NM_002828
RefSeq Synonyms
NM_080423, NM_080422, NM_002828, NM_001308287, NM_001207013, BC016727, BC008244,
Research Areas
Cytokine Signaling,HGF Signaling,IFN Signaling,Immunology,Insulin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,PDGF Signaling,Phosphatase,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
The gene PTPN2, also known as TCPTP or TCP-TP, encodes for the protein tyrosine phosphatase (PTP) family member, tyrosine-protein phosphatase non-receptor type 2. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN2 dephosphorylates both receptor and non-receptor protein tyrosine kinases. PTPN2/TCPTP negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis [taken from NCBI Entrez Gene (Gene ID: 5771) and UniProtKB (Entry: P17706)].
UniGene ID
Hs.654527
UniProt ID (eCommerce)
P17706

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.