human FERMT2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FERMT2.
shADV-208909
Ad-h-FERMT2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FERMT2 (fermitin family member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
fermitin family homolog 2; KIND2; kindlin 2; Kindlin-2; MIG2; mig-2; mitogen inducible gene 2 protein; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; UNC112; UNC112B
Description (eCommerce)
Kindlin-2 is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. It binds to membranes enriched in phosphoinositides. It also enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Kindlin-2 is required for the assembly of focal adhesions and participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Kindlin-2 recruits FBLIM1 to focal adhesions. It plays a role in the TGFB1 and integrin signaling pathways, and it stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96AC1].
Gene ID
10979
Gene Name (eCommerce)
fermitin family member 2
Gene Name (Vector)
fermitin family member 2
Gene Symbol
FERMT2
HGNC ID
HGNC:15767
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2043
ORF Size (bp)
2043 bp
Protein Name (eCommerce)
Fermitin family homolog 2
RefSeq ID
NM_006832
RefSeq Synonyms
NM_006832, NM_001135000, NM_001134999, BC017327,
Research Areas
Cytoskeleton,Immunology,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Kindlin-2 is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. It binds to membranes enriched in phosphoinositides. It also enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Kindlin-2 is required for the assembly of focal adhesions and participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Kindlin-2 recruits FBLIM1 to focal adhesions. It plays a role in the TGFB1 and integrin signaling pathways, and it stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96AC1].
UniGene ID
Hs.509343
UniProt ID (eCommerce)
Q96AC1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.