human F3 shRNA silencing Adenovirus

Name
Ad-h-F3-shRNA

Cat No
shADV-208229

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human F3.

shADV-208229

Ad-h-F3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human F3 (coagulation factor III, tissue factor). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CD142; TF; TFA

Description (Vector)

F3 encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Gene ID

2152

Gene Name (Vector)

coagulation factor III, tissue factor

Gene Symbol

HGNC ID

HGNC:3541

ORF Size (aa)

888

ORF Size (bp)

888 bp

RefSeq ID

NM_001993

RefSeq Synonyms

NM_001993, NM_001178096, BC011029,

Species

human

UniGene ID

Hs.62192

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.