human ESCO2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ESCO2.
shADV-208104
Ad-h-ESCO2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2410004I17Rik; ECO1 homolog 2; EFO2; Establishment of cohesion 1 homolog 2; N-acetyltransferase ESCO2; RBS
Description (eCommerce)
ESCO2 (establishment of cohesion 1 homolog2) is an acetyltransferase that is essential to sister chromatid cohesion during S phase. Recent studies reveal that ESCO2 associates with components of the CoREST transcriptional repression complex. ESCO2 has also been shown to possess histone H3 K9 methylation activity. These findings suggest a role for ESCO2 in transcriptional regulation via the modulation of chromatin structure.
Description (Vector)
ESCO2 encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome.
Gene ID
157570
Gene Name (eCommerce)
establishment of sister chromatid cohesion N-acetyltransferase 2
Gene Name (Vector)
establishment of sister chromatid cohesion N-acetyltransferase 2
Gene Symbol
ESCO2
HGNC ID
HGNC:27230
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1806
ORF Size (bp)
1806 bp
Protein Name (eCommerce)
N-acetyltransferase ESCO2
RefSeq ID
NM_001017420
RefSeq Synonyms
NM_001017420, BC146562, BC141418,
Research Areas
Acyltransferase,Cell Cycle,Cell Division,DNA Replication,Translational Control,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
ESCO2 (establishment of cohesion 1 homolog2) is an acetyltransferase that is essential to sister chromatid cohesion during S phase. Recent studies reveal that ESCO2 associates with components of the CoREST transcriptional repression complex. ESCO2 has also been shown to possess histone H3 K9 methylation activity. These findings suggest a role for ESCO2 in transcriptional regulation via the modulation of chromatin structure.
UniGene ID
Hs.99480
UniProt ID (eCommerce)
Q56NI9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.