human ERCC3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ERCC3.
shADV-208060
Ad-h-ERCC3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
basic transcription factor 2 89 kDa subunit; BTF2; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair helicase; DNA repair protein complementing XP-B cells; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; general transcription and DNA repair factor IIH helicase subunit XPB; GTF2H; RAD25; TFIIH; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; TFIIH subunit XPB; TTD2; xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B; XPB
Description (eCommerce)
ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3’-5’ DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.
Description (Vector)
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.
Gene ID
2071
Gene Name (eCommerce)
ERCC excision repair 3, TFIIH core complex helicase subunit
Gene Name (Vector)
ERCC excision repair 3, TFIIH core complex helicase subunit
Gene Symbol
ERCC3
HGNC ID
HGNC:3435
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2349
ORF Size (bp)
2349 bp
Protein Name (eCommerce)
TFIIH basal transcription factor complex helicase XPB subunit
RefSeq ID
NM_000122
RefSeq Synonyms
NM_001303418, NM_001303416, NM_000122, BC008820,
Research Areas
Apoptosis,Cell Cycle,DNA Damage/Repair,Epigenetic Regulation of Gene Expression,Gene Expression,Helicase Activity,Host-Virus Interactions,Hypoxia,mRNA Processing,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease,transcription_translation
Species
human
Target Sentence
ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3’-5’ DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.
UniGene ID
Hs.469872
UniProt ID (eCommerce)
P19447
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.