human EHHADH shRNA silencing Adenovirus

Name 
Ad-h-EHHADH-shRNA
Cat No 
shADV-207686
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EHHADH.

shADV-207686
Ad-h-EHHADH-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; ECHD; Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; FRTS3; L-3-hydroxyacyl-CoA dehydrogenase; LBFP; L-bifunctional protein, peroxisomal; LBP; L-PBE; PBE; PBFE; peroxisomal bifunctional enzyme; peroxisomal enoyl-CoA hydratase
Description (eCommerce)
Peroxisomal bifunctional enzyme (PBE) is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of PBE contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in the PBE gene are a cause of peroxisomal disorders such as Zellweger syndrome [taken from NCBI Entrez Gene (Gene ID: 1962)].
Description (Vector)
EHHADH is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1962
Gene Name (eCommerce)
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Gene Name (Vector)
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Gene Symbol
EHHADH
HGNC ID
HGNC:3247
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2172
ORF Size (bp)
2172 bp
Protein Name (eCommerce)
Peroxisomal bifunctional enzyme
RefSeq ID
NM_001966
RefSeq Synonyms
NM_001966, NM_001166415, BC110460, BC038948,
Research Areas
Cytoskeleton,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism
Species
human
Target Sentence
Peroxisomal bifunctional enzyme (PBE) is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of PBE contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in the PBE gene are a cause of peroxisomal disorders such as Zellweger syndrome [taken from NCBI Entrez Gene (Gene ID: 1962)].
UniGene ID
Hs.429879
UniProt ID (eCommerce)
Q08426

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.