rat RING1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Ring1.
shAAV-294074
AAV-r-RING1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Ring1 (ring finger protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Ring1A
Description (Vector)
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
Gene ID
309626
Gene Name (Vector)
ring finger protein 1
Gene Symbol
Ring1
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
RefSeq ID
NM_212549
RefSeq Synonyms
NM_212549, BC098635,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.