rat RFWD2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Rfwd2.
shAAV-293448
AAV-r-RFWD2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Rfwd2 (ring finger and WD repeat domain 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cop1; RGD1304773
Description (Vector)
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.
Gene ID
360860
Gene Name (Vector)
ring finger and WD repeat domain 2
Gene Symbol
Rfwd2
ORF Size (aa)
1302
ORF Size (bp)
1302 bp
RefSeq ID
NM_001025126
RefSeq Synonyms
NM_001025126, BC091284,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.