mouse RFX6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rfx6.
shAAV-270452
AAV-m-RFX6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rfx6 (regulatory factor X, 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4930572O07Rik; Rfxdc1
Description (Vector)
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes.
Gene ID
320995
Gene Name (Vector)
regulatory factor X, 6
Gene Symbol
Rfx6
ORF Size (aa)
1992
ORF Size (bp)
1992 bp
RefSeq ID
NM_177306
RefSeq Synonyms
NM_177306, NM_001159389, BC132294, BC132104,
Species
mouse
UniGene ID
Mm.109190
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.