mouse RASGRP1 shRNA silencing AAV

Name
AAV-m-RASGRP1-shRNA

Cat No
shAAV-270173

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Rasgrp1.

shAAV-270173

AAV-m-RASGRP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Rasgrp1 (RAS guanyl releasing protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Rasgrp

Description (Vector)

Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.

Gene ID

19419

Gene Name (Vector)

RAS guanyl releasing protein 1

Gene Symbol

Rasgrp1

ORF Size (aa)

2388

ORF Size (bp)

2388 bp

RefSeq ID

NM_011246

RefSeq Synonyms

NM_011246, BC057341, BC057120,

Species

mouse

UniGene ID

Mm.42150

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.