mouse ERCC2 shRNA silencing AAV

Name 
AAV-m-ERCC2-shRNA
Cat No 
shAAV-258632
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Ercc2.

shAAV-258632
AAV-m-ERCC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AA407812; AU020867; AW240756; CXPD; Ercc-2; Mhdarco15; RCO015; XPD
Description (Vector)
ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Gene ID
13871
Gene Name (Vector)
excision repair cross-complementing rodent repair deficiency, complementation group 2
Gene Symbol
Ercc2
ORF Size (aa)
2220
ORF Size (bp)
2220 bp
RefSeq ID
NM_007949
RefSeq Synonyms
NM_007949, BC034517,
Species
mouse
UniGene ID
Mm.36524

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.