mouse EPHA7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Epha7.
shAAV-258574
AAV-m-EPHA7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Epha7 (Eph receptor A7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cek11; Ebk; Ehk3; Hek11; Mdk1
Description (Vector)
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Gene ID
13841
Gene Name (Vector)
Eph receptor A7
Gene Symbol
Epha7
ORF Size (aa)
2985
ORF Size (bp)
2985 bp
RefSeq ID
NM_010141
RefSeq Synonyms
NM_010141, NM_001290434, NM_001122889, BC026153,
Species
mouse
UniGene ID
Mm.257266
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.