human SSR1 shRNA silencing AAV

Name 
AAV-h-SSR1-shRNA
Cat No 
shAAV-224396
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SSR1.

shAAV-224396
AAV-h-SSR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SSR1 (signal sequence receptor subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
signal sequence receptor subunit alpha; signal sequence receptor, alpha; SSR alpha subunit; SSR-alpha; translocon-associated protein alpha subunit; translocon-associated protein subunit alpha; TRAP alpha; TRAPA; TRAP-alpha
Description (eCommerce)
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SSR1/TRAP may be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P43307].
Description (Vector)
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical.
Gene ID
6745
Gene Name (eCommerce)
signal sequence receptor subunit 1
Gene Name (Vector)
signal sequence receptor subunit 1
Gene Symbol
SSR1
HGNC ID
HGNC:11323
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
861
Protein Name (eCommerce)
Translocon-associated protein subunit alpha
RefSeq ID
NM_003144
RefSeq Synonyms
NM_003144, NM_001292008, BC007710,
Research Areas
Gene Expression,Metabolism/Metabolic Process,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SSR1/TRAP may be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P43307].
UniGene ID
Hs.114033
UniProt ID (eCommerce)
P43307

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.