human SAP130 shRNA silencing AAV

Name 
AAV-h-SAP130-shRNA
Cat No 
shAAV-222233
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SAP130.

shAAV-222233
AAV-h-SAP130-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SAP130 (Sin3A associated protein 130). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
130 kDa Sin3-associated polypeptide; histone deacetylase complex subunit SAP130; Sin3A associated protein 130kDa; Sin3-associated polypeptide p130
Description (eCommerce)
Sin3-associated polypeptide p130 (SAP130) is a component of an mSin3A corepressor complex. SAP130 acts as a transcriptional repressor. It may function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0E3].
Description (Vector)
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 (PubMed 12724404)).(supplied by OMIM, Mar 2008)
Gene ID
79595
Gene Name (eCommerce)
Sin3A associated protein 130
Gene Name (Vector)
Sin3A associated protein 130
Gene Symbol
SAP130
HGNC ID
HGNC:29813
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3252
ORF Size (bp)
3252 bp
Protein Name (eCommerce)
Histone deacetylase complex subunit SAP130
RefSeq ID
NM_024545
RefSeq Synonyms
NM_024545, NM_001330303, NM_001330302, NM_001330301, NM_001330300, NM_001330299, NM_001145928, BC143898, BC117255, BC017453,
Research Areas
Epigenetic Regulation of Gene Expression,Histone Modification,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Sin3-associated polypeptide p130 (SAP130) is a component of an mSin3A corepressor complex. SAP130 acts as a transcriptional repressor. It may function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0E3].
UniGene ID
Hs.32995
UniProt ID (eCommerce)
Q9H0E3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.