human S1PR5 shRNA silencing AAV

Name
AAV-h-S1PR5-shRNA

Cat No
shAAV-222191

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human S1PR5.

shAAV-222191

AAV-h-S1PR5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human S1PR5 (sphingosine-1-phosphate receptor 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Edg-8; EDG8; S1P5; SPPR-1; SPPR-2

Description (Vector)

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.(supplied by OMIM, Mar 2008)

Gene ID

53637

Gene Name (Vector)

sphingosine-1-phosphate receptor 5

Gene Symbol

S1PR5

HGNC ID

HGNC:14299

ORF Size (aa)

1197

ORF Size (bp)

1197 bp

RefSeq ID

NM_030760

RefSeq Synonyms

NM_030760, NM_001166215, BC067781, BC034703,

Species

human

UniGene ID

Hs.501561

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.