human RTKN shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RTKN.
shAAV-222083
AAV-h-RTKN-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RTKN (rhotekin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
6242
Gene Name (Vector)
rhotekin
Gene Symbol
RTKN
HGNC ID
HGNC:10466
ORF Size (aa)
1692
ORF Size (bp)
1692 bp
RefSeq ID
NM_033046
RefSeq Synonyms
NM_033046, NM_001015056, NM_001015055, BC017727, BC004558,
Species
human
UniGene ID
Hs.192854
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.