human RPS6KA2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RPS6KA2.
shAAV-221934
AAV-h-RPS6KA2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RPS6KA2 (ribosomal protein S6 kinase A2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
90 kDa ribosomal protein S6 kinase 2; HU-2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1C; MAPKAPK1C; MAPKAPK-1c; mitogen-activated protein kinase-activated protein kinase 1C; p90-RSK 2; p90RSK2; p90-RSK3; pp90RSK3; ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; ribosomal S6 kinase 3; RSK; RSK3; RSK-3; S6K-alpha; S6K-alpha2; S6K-alpha-2
Description (eCommerce)
RSK3 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15349].
Description (Vector)
RPS6KA2 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
6196
Gene Name (eCommerce)
ribosomal protein S6 kinase A2
Gene Name (Vector)
ribosomal protein S6 kinase A2
Gene Symbol
RPS6KA2
HGNC ID
HGNC:10431
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2202
ORF Size (bp)
2202 bp
Protein Name (eCommerce)
Ribosomal protein S6 kinase alpha-2
RefSeq ID
NM_021135
RefSeq Synonyms
NM_021135, NM_001318938, NM_001318937, NM_001318936, NM_001006932, BC002363,
Research Areas
Apoptosis,Axon Guidance,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,EGFR Signaling,EPO Signaling,Gene Expression,GPCR Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,MAPK Signaling,Meiosis,mTOR Signaling,Neurobiology,NGF Signaling,Prolactin Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
RSK3 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15349].
UniGene ID
Hs.655277
UniProt ID (eCommerce)
Q15349
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.