human RPL6 shRNA silencing AAV

Name
AAV-h-RPL6-shRNA

Cat No
shAAV-221727

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RPL6.

shAAV-221727

AAV-h-RPL6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPL6 (ribosomal protein L6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

60S ribosomal protein L6; DNA-binding protein TAXREB107; L6; large ribosomal subunit protein eL6; neoplasm-related protein C140; SHUJUN-2; TAXREB107; tax-responsive enhancer element-binding protein 107; TXREB1

Description (eCommerce)

Ribosomal Protein L6 (RPL6) is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis.

Description (Vector)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene ID

6128

Gene Name (eCommerce)

ribosomal protein L6

Gene Name (Vector)

ribosomal protein L6

Gene Symbol

RPL6

HGNC ID

HGNC:10362

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

867

Protein Name (eCommerce)

60S ribosomal protein L6

RefSeq ID

NM_000970

RefSeq Synonyms

NM_001320142, NM_001320141, NM_001320140, NM_001320139, NM_001320138, NM_001320137, NM_001024662, NM_000970, BC104826, BC104824, BC071912, BC032299, BC031009, BC022444, BC020679, BC004138,

Research Areas

Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Signal Transduction,TNF Signaling,Transcription Factor/Regulator,Translational Control

Research Areas (Faceted)

cell_biology,genetics,infectious_disease,metabolism,signal_transduction,transcription_translation

Species

human

Target Sentence

Ribosomal Protein L6 (RPL6) is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis.

UniGene ID

Hs.546283

UniProt ID (eCommerce)

Q02878

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.