human RNH1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RNH1.
shAAV-221445
AAV-h-RNH1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RNH1 (ribonuclease/angiogenin inhibitor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
placental ribonuclease inhibitor; placental RNase inhibitor; RAI; ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1; RNH; testicular tissue protein Li 164
Description (eCommerce)
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo [taken from NCBI Entrez Gene (Gene ID: 6050)].
Description (Vector)
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 (PubMed 3219362)). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.(supplied by OMIM, Jul 2010)
Gene ID
6050
Gene Name (eCommerce)
ribonuclease/angiogenin inhibitor 1
Gene Name (Vector)
ribonuclease/angiogenin inhibitor 1
Gene Symbol
RNH1
HGNC ID
HGNC:10074
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1386
ORF Size (bp)
1386 bp
Protein Name (eCommerce)
Ribonuclease inhibitor
RefSeq ID
NM_002939
RefSeq Synonyms
NM_203389, NM_203388, NM_203387, NM_203386, NM_203385, NM_203384, NM_203383, NM_002939, BC047730, BC024037, BC014629, BC011500, BC003506, BC000677,
Research Areas
Angiogenesis,RNA Processing
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo [taken from NCBI Entrez Gene (Gene ID: 6050)].
UniGene ID
Hs.530687
UniProt ID (eCommerce)
P13489
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.