human RFX6 shRNA silencing AAV

Name
AAV-h-RFX6-shRNA

Cat No
shAAV-221074

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RFX6.

shAAV-221074

AAV-h-RFX6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RFX6 (regulatory factor X6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

dJ955L16.1; MTCHRS; MTFS; RFXDC1

Description (Vector)

The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.

Gene ID

222546

Gene Name (Vector)

regulatory factor X6

Gene Symbol

RFX6

HGNC ID

HGNC:21478

ORF Size (aa)

2787

ORF Size (bp)

2787 bp

RefSeq ID

NM_173560

RefSeq Synonyms

NM_173560, BC039248,

Species

human

UniGene ID

Hs.352276

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.