human RECQL5 shRNA silencing AAV

Name 
AAV-h-RECQL5-shRNA
Cat No 
shAAV-220976
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RECQL5.

shAAV-220976
AAV-h-RECQL5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RECQL5 (RecQ like helicase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATP-dependent DNA helicase Q5; DNA helicase, RecQ-like type 5; RecQ helicase-like 5; RecQ protein-like 5; RECQ5
Description (eCommerce)
RECQ5 is one of five human homologs of RecQ DNA helicases. RecQ helicases function in DNA replication and repair and are important to genomic stability. Mutations in the genes encoding BLM (RECQL2), WRN (RECQL3), and RECQL4 result in a predisposition to cancer. No heritable disease has been found to be associated with RECQL5.
Description (Vector)
RECQL5 is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
9400
Gene Name (eCommerce)
RecQ like helicase 5
Gene Name (Vector)
RecQ like helicase 5
Gene Symbol
RECQL5
HGNC ID
HGNC:9950
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2895
ORF Size (bp)
2895 bp
Protein Name (eCommerce)
ATP-dependent DNA helicase Q5
RefSeq ID
NM_001003715
RefSeq Synonyms
NM_004259, NM_001003716, NM_001003715, BC063440,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,DNA Replication,Helicase Activity
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
RECQ5 is one of five human homologs of RecQ DNA helicases. RecQ helicases function in DNA replication and repair and are important to genomic stability. Mutations in the genes encoding BLM (RECQL2), WRN (RECQL3), and RECQL4 result in a predisposition to cancer. No heritable disease has been found to be associated with RECQL5.
UniGene ID
Hs.632229
UniProt ID (eCommerce)
O94762

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.