human RAB3GAP1 shRNA silencing AAV

Name
AAV-h-RAB3GAP1-shRNA

Cat No
shAAV-220552

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RAB3GAP1.

shAAV-220552

AAV-h-RAB3GAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

P130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; rab3 GTPase-activating protein catalytic subunit; RAB3GAP; Rab3-GAP; rab3-GAP p130; RAB3GAP130; WARBM1

Description (eCommerce)

Rab3-GAP1 is the catalytic subunit of Rab3-GAP. Rab3-GAP is a key regulator of calcium-mediated hormone and neurotransmitter exocytosis. Defects in Rab3-GAP1 are the cause of Warburg micro syndrome 1 (WARBM1) a disorder characterized by severe developmental abnormalities of the eye and central nervous system.

Description (Vector)

RAB3GAP1 encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.

Gene ID

22930

Gene Name (eCommerce)

RAB3 GTPase activating protein catalytic subunit 1

Gene Name (Vector)

RAB3 GTPase activating protein catalytic subunit 1

Gene Symbol

RAB3GAP1

HGNC ID

HGNC:17063

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2808

ORF Size (bp)

2808 bp

Protein Name (eCommerce)

Rab3 GTPase-activating protein catalytic subunit

RefSeq ID

NM_012233

RefSeq Synonyms

NM_012233, NM_001172435, BC146809,

Research Areas

Brain Development,Neurobiology,Neurodevelopment,Signal Transduction,Transport

Research Areas (Faceted)

cell_biology,developmental_biology,neurobiology,signal_transduction

Species

human

Target Sentence

Rab3-GAP1 is the catalytic subunit of Rab3-GAP. Rab3-GAP is a key regulator of calcium-mediated hormone and neurotransmitter exocytosis. Defects in Rab3-GAP1 are the cause of Warburg micro syndrome 1 (WARBM1) a disorder characterized by severe developmental abnormalities of the eye and central nervous system.

UniGene ID

Hs.306327

UniProt ID (eCommerce)

Q15042

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.