human PYGB shRNA silencing AAV

Name
AAV-h-PYGB-shRNA

Cat No
shAAV-220445

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PYGB.

shAAV-220445

AAV-h-PYGB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PYGB (glycogen phosphorylase B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GPBB

Description (Vector)

PYGB is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

Gene ID

5834

Gene Name (Vector)

glycogen phosphorylase B

Gene Symbol

PYGB

HGNC ID

HGNC:9723

ORF Size (aa)

2532

ORF Size (bp)

2532 bp

RefSeq ID

NM_002862

RefSeq Synonyms

NM_002862, BC030795, BC017045,

Species

human

UniGene ID

Hs.368157

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.