human PTPN20B shRNA silencing AAV

Name
AAV-h-PTPN20B-shRNA

Cat No
shAAV-220318

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTPN20.

shAAV-220318

AAV-h-PTPN20B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPN20 (protein tyrosine phosphatase, non-receptor type 20). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA142I17.1; bA42B19.1; CT126; PTPN20A; PTPN20B

Description (Vector)

The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

26095

Gene Name (Vector)

protein tyrosine phosphatase, non-receptor type 20

Gene Symbol

PTPN20

HGNC ID

HGNC:23423

ORF Size (aa)

678

RefSeq ID

NM_015605

RefSeq Synonyms

NM_015605, NM_001320691, NM_001320690, NM_001320689, NM_001320688, NM_001320686, NM_001320685, NM_001320684, NM_001320683, NM_001320682, NM_001320681, NM_001042365, NM_001042364, NM_001042363, NM_001042362, NM_001042361, NM_001042360, NM_001042359, NM_001042358, NM_001042357, BC141460, BC036539,

Species

human

UniGene ID

Hs.499552

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.