human PSIP1 shRNA silencing AAV

Name
AAV-h-PSIP1-shRNA

Cat No
shAAV-220082

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PSIP1.

shAAV-220082

AAV-h-PSIP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PSIP1 (PC4 and SFRS1 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLL-associated antigen KW-7; dense fine speckles 70 kDa protein; DFS 70; DFS70; LEDGF; lens epithelium-derived growth factor; p52; p75; PAIP; PC4 and SFRS1-interacting protein; PSIP2; transcriptional coactivator p52/p75; Transcriptional coactivator p75/p52

Description (eCommerce)

LEDGF/p75 has been identified as a transcriptional coactivator involved in lens epithelial cell gene regulation and in neuroepithelial stem cell differentiation and neurogenesis. LEDGF has also been shown to function as a cofactor for lentivirus and HIV integration.

Gene ID

11168

Gene Name (eCommerce)

PC4 and SFRS1 interacting protein 1

Gene Name (Vector)

PC4 and SFRS1 interacting protein 1

Gene Symbol

PSIP1

HGNC ID

HGNC:9527

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

975

ORF Size (bp)

975 bp

Protein Name (eCommerce)

PC4 and SFRS1-interacting protein

RefSeq ID

NM_021144

RefSeq Synonyms

NM_033222, NM_021144, NM_001317900, NM_001317898, NM_001128217, BC064135, BC044568,

Research Areas

Host-Virus Interactions,Neurobiology,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,infectious_disease,neurobiology,transcription_translation

Species

human

Target Sentence

LEDGF/p75 has been identified as a transcriptional coactivator involved in lens epithelial cell gene regulation and in neuroepithelial stem cell differentiation and neurogenesis. LEDGF has also been shown to function as a cofactor for lentivirus and HIV integration.

UniGene ID

Hs.658434

UniProt ID (eCommerce)

O75475

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.