human PRPF6 shRNA silencing AAV

Name
AAV-h-PRPF6-shRNA

Cat No
shAAV-219963

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PRPF6.

shAAV-219963

AAV-h-PRPF6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRPF6 (pre-mRNA processing factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

androgen receptor N-terminal domain transactivating protein-1; Androgen receptor N-terminal domain-transactivating protein 1; ANT1; ANT-1; C20orf14; hPrp6; p102 U5 small nuclear ribonucleoprotein particle-binding protein; pre-mRNA-processing factor 6; Prp6; PRP6 homolog; PRP6 pre-mRNA processing factor 6 homolog; putative mitochondrial outer membrane protein import receptor; RP60; SNRNP102; TOM; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein; U5-102K

Description (eCommerce)

Pre-mRNA-processing factor 6 (PRP6) is involved in pre-mRNA splicing. PRP6 may act in the tri-snRNP complex as a bridging factor between U5 and U4/U6 snRNPs in the late step of spliceosome assembly. It may be necessary for tri-snRNP formation [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/O94906].

Description (Vector)

PRPF6 appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.

Gene ID

24148

Gene Name (eCommerce)

pre-mRNA processing factor 6

Gene Name (Vector)

pre-mRNA processing factor 6

Gene Symbol

PRPF6

HGNC ID

HGNC:15860

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2826

ORF Size (bp)

2826 bp

Protein Name (eCommerce)

Pre-mRNA-processing factor 6

RefSeq ID

NM_012469

RefSeq Synonyms

NM_012469, BC001666,

Research Areas

Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome,Transcription Factor/Regulator

Research Areas (Faceted)

genetics,transcription_translation,cell_biology

Species

human

Target Sentence

Pre-mRNA-processing factor 6 (PRP6) is involved in pre-mRNA splicing. PRP6 may act in the tri-snRNP complex as a bridging factor between U5 and U4/U6 snRNPs in the late step of spliceosome assembly. It may be necessary for tri-snRNP formation [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/O94906].

UniGene ID

Hs.31334

UniProt ID (eCommerce)

O94906

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.