human GPT shRNA silencing AAV

Cat. No: shAAV-210451

Availability: 4-5 weeks

Name: AAV-h-GPT-shRNA

This is an AAV expressing shRNA for silencing of Human GPT.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GPT
Gene Name: glutamic--pyruvic transaminase
Gene ID: 2875
Gene Synonyms: AAT1; ALT1; GPT1
ORF Size: 1491 bp
RefSeq#: NM_005309
Gene Description: GPT encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
UniGene ID: Hs.103502
HGNC ID: HGNC:4552