human FKBP4 shRNA silencing AAV

51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506-binding protein 4; FKBP-4; FKBP51; FKBP52; FKBP-52; FKBP59; HBI; HSP binding immunophilin; Hsp56; HSP-binding immunophilin; Immunophilin FKBP52; p52; p59; peptidylprolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP4; PPIase; PPIase FKBP4; rotamase; T-cell FK506-binding protein, 59kD

FKBP4/FKBP52 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP52 exhibits peptidyl-prolyl cis-trans isomerase activity, but does not appear to mediate the immunosuppressive activities of FK506. The most studied role of FKBP4/FKBP52 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperone Hsp90, FKBP4/FKBP52 is able to influence steroid-hormone binding affinity and transcriptional activity.

FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.

2288

FK506 binding protein 4

FK506 binding protein 4

FKBP4

HGNC:3720

9606.0

1380

1380 bp

Peptidyl-prolyl cis-trans isomerase FKBP4

NM_002014

NM_002014, BC007924, BC001786,

Cytoskeleton,Estrogen Signaling,Mitochondrion,Neurobiology,Neurodevelopment,Protein Folding,Signal Transduction

cell_biology,developmental_biology,neurobiology,signal_transduction

human

FKBP4/FKBP52 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP52 exhibits peptidyl-prolyl cis-trans isomerase activity, but does not appear to mediate the immunosuppressive activities of FK506. The most studied role of FKBP4/FKBP52 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperone Hsp90, FKBP4/FKBP52 is able to influence steroid-hormone binding affinity and transcriptional activity.

Hs.713721

Q02790