human FGFR4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human FGFR4.
shAAV-208997
AAV-h-FGFR4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human FGFR4 (fibroblast growth factor receptor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD334; JTK2; TKF
Description (Vector)
FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Gene ID
2264
Gene Name (Vector)
fibroblast growth factor receptor 4
Gene Symbol
FGFR4
HGNC ID
HGNC:3691
ORF Size (aa)
2409
ORF Size (bp)
2409 bp
RefSeq ID
NM_002011
RefSeq Synonyms
NM_213647, NM_022963, NM_002011, NM_001291980, BC011847,
Species
human
UniGene ID
Hs.165950
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.