human FANCE shRNA silencing AAV

Name 
AAV-h-FANCE-shRNA
Cat No 
shAAV-208696
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FANCE.

shAAV-208696
AAV-h-FANCE-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FANCE (Fanconi anemia complementation group E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FACE; FAE; Fanconi anemia complementation group E; Fanconi anemia group E protein; Protein FACE
Description (eCommerce)
FANCE (Fanconi anemia, complementation group E) is a protein involved in DNA repair. Defects in FANCE are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCE gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. FANCE has been shown to mediate the interaction between FANCC and FANCD2.
Description (Vector)
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E.
Gene ID
2178
Gene Name (eCommerce)
FA complementation group E
Gene Name (Vector)
Fanconi anemia complementation group E
Gene Symbol
FANCE
HGNC ID
HGNC:3586
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
Protein Name (eCommerce)
Fanconi anemia group E protein
RefSeq ID
NM_021922
RefSeq Synonyms
NM_021922, BC046359,
Research Areas
Cancer,DNA Damage/Repair,Fanconi anemia,Homologous Recombination,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
FANCE (Fanconi anemia, complementation group E) is a protein involved in DNA repair. Defects in FANCE are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCE gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. FANCE has been shown to mediate the interaction between FANCC and FANCD2.
UniGene ID
Hs.302003
UniProt ID (eCommerce)
Q9HB96

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.