human FAM120A shRNA silencing AAV

Name
AAV-h-FAM120A-shRNA

Cat No
shAAV-208353

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FAM120A.

shAAV-208353

AAV-h-FAM120A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FAM120A (family with sequence similarity 120A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C9orf10; constitutive coactivator of PPAR-gamma-like protein 1; HBVPTPAP; OSSA; oxidative stess-associated Src activator; oxidative stress-associated Src activator; Protein FAM120A

Description (eCommerce)

Oxidative stress-associated Src activator (OSSA) may participate in mRNA transport in the cytoplasm (by similarity). OSSA is a critical component of the oxidative stress-induced survival signaling. It activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. It binds RNA and promotes the secretion of IGF-II. OSSA may play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZB2].

Gene ID

23196

Gene Name (eCommerce)

family with sequence similarity 120A

Gene Name (Vector)

family with sequence similarity 120A

Gene Symbol

FAM120A

HGNC ID

HGNC:13247

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3357

ORF Size (bp)

3357 bp

Protein Name (eCommerce)

Constitutive coactivator of PPAR-gamma-like protein 1

RefSeq ID

NM_014612

RefSeq Synonyms

NM_014612, NM_001286724, NM_001286723, NM_001286722, BC111736, BC098584,

Research Areas

Cancer,RNA Binding,Transport,Tumor Suppressors/Oncoproteins

Research Areas (Faceted)

cancer,cell_biology

Species

human

Target Sentence

Oxidative stress-associated Src activator (OSSA) may participate in mRNA transport in the cytoplasm (by similarity). OSSA is a critical component of the oxidative stress-induced survival signaling. It activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. It binds RNA and promotes the secretion of IGF-II. OSSA may play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZB2].

UniGene ID

Hs.707324

UniProt ID (eCommerce)

Q9NZB2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.