human EPX shRNA silencing AAV

Name
AAV-h-EPX-shRNA

Cat No
shAAV-208033

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human EPX.

shAAV-208033

AAV-h-EPX-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EPX (eosinophil peroxidase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EPO; EPP; EPX-PEN; EPXD

Description (Vector)

EPX is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency.

Gene ID

8288

Gene Name (Vector)

eosinophil peroxidase

Gene Symbol

EPX

HGNC ID

HGNC:3423

ORF Size (aa)

2148

ORF Size (bp)

2148 bp

RefSeq ID

NM_000502

RefSeq Synonyms

NM_000502, BC111602,

Species

human

UniGene ID

Hs.279259

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.