human EIF2B4 shRNA silencing AAV

Name 
AAV-h-EIF2B4-shRNA
Cat No 
shAAV-207717
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EIF2B4.

shAAV-207717
AAV-h-EIF2B4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
EIF2B; EIF-2B; eIF-2B GDP-GTP exchange factor subunit delta; EIF2Bdelta; eukaryotic translation initiation factor 2B subunit 4 delta; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; translation initiation factor eIF-2b delta subunit; translation initiation factor eIF-2B subunit delta
Description (eCommerce)
eIF2B delta is encoded by the EIF2B4 gene. EIF2B4 is necessary for protein synthesis and is one of five subunits of the eIF2B factor which functions as a GTP exchange factor. The protein encoded by this gene, EIF2B4, is the fourth, or delta subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy.
Description (Vector)
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
8890
Gene Name (eCommerce)
eukaryotic translation initiation factor 2B subunit delta
Gene Name (Vector)
eukaryotic translation initiation factor 2B subunit delta
Gene Symbol
EIF2B4
HGNC ID
HGNC:3260
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1572
ORF Size (bp)
1572 bp
Protein Name (eCommerce)
Translation initiation factor eIF-2B subunit delta
RefSeq ID
NM_015636
RefSeq Synonyms
NM_172195, NM_015636, NM_001318969, NM_001318968, NM_001318967, NM_001318966, NM_001318965, NM_001034116, BC091502, BC001870,
Research Areas
Gene Expression,Metabolism/Metabolic Process,Neurobiology,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,metabolism,neurobiology,cell_biology
Species
human
Target Sentence
eIF2B delta is encoded by the EIF2B4 gene. EIF2B4 is necessary for protein synthesis and is one of five subunits of the eIF2B factor which functions as a GTP exchange factor. The protein encoded by this gene, EIF2B4, is the fourth, or delta subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy.
UniGene ID
Hs.169474
UniProt ID (eCommerce)
Q9UI10

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.