human EHMT2 shRNA silencing AAV

Name 
AAV-h-EHMT2-shRNA
Cat No 
shAAV-207689
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EHMT2.

shAAV-207689
AAV-h-EHMT2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EHMT2 (euchromatic histone lysine methyltransferase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ankyrin repeat-containing protein; BAT8; C6orf30; euchromatic histone-lysine N-methyltransferase 2; G9A; G9A histone methyltransferase; GAT8; H3-K9-HMTase 3; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase EHMT2; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; HLA-B associated transcript 8; HLA-B-associated transcript 8; KMT1C; lysine N-methyltransferase 1C; NG36; Protein G9a
Description (eCommerce)
G9A/EHMT2 is a histone H3-Lys-9 methyltransferase. G9A/EHMT2 has been shown to function as a corepressor by associating with transcriptional regulators such as CDP/cut, Blimp-1/PRDI-BF1, and REST/NRSF. G9A/EHMT2 has also been shown to function as a coactivator for a large family of nuclear receptors.
Description (Vector)
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.
Gene ID
10919
Gene Name (eCommerce)
euchromatic histone lysine methyltransferase 2
Gene Name (Vector)
euchromatic histone lysine methyltransferase 2
Gene Symbol
EHMT2
HGNC ID
HGNC:14129
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3006
ORF Size (bp)
3006 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase EHMT2
RefSeq ID
NM_025256
RefSeq Synonyms
NM_025256, NM_006709, NM_001318833, NM_001289413, BC020970, BC018718,
Research Areas
Chromatin Remodeling,DNA Replication,Gene Expression,Histone Modification,Methyltransferase,Neurobiology
Research Areas (Faceted)
genetics,transcription_translation,cell_biology,neurobiology
Species
human
Target Sentence
G9A/EHMT2 is a histone H3-Lys-9 methyltransferase. G9A/EHMT2 has been shown to function as a corepressor by associating with transcriptional regulators such as CDP/cut, Blimp-1/PRDI-BF1, and REST/NRSF. G9A/EHMT2 has also been shown to function as a coactivator for a large family of nuclear receptors.
UniGene ID
Hs.709218
UniProt ID (eCommerce)
Q96KQ7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.