mouse EPHB1 Adenovirus
This is an Adenovirus expressing Mouse Ephb1.
ADV-258576
Ad-m-EPHB1
Ready-to-use Adenovirus expressing Mouse Ephb1 (Eph receptor B1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9330129L11; AW488255; C130099E04Rik; Cek6; Elk; Elkh; ENSMUSG00000074119; Hek6; Net
Description (Vector)
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
Gene ID
270190
Gene Name (Vector)
Eph receptor B1
Gene Symbol
Ephb1
ORF Size (aa)
2955
ORF Size (bp)
2955 bp
RefSeq ID
NM_173447
RefSeq Synonyms
NM_173447, NM_001168296, BC057301,
Species
mouse
UniGene ID
Mm.22897
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.