mouse CTNNB1 Adenovirus

Name
Ad-m-CTNNB1

Cat No
ADV-256317

Availability
4-5 weeks

This is an Adenovirus expressing Mouse CTNNB1.

ADV-256317

Ad-m-CTNNB1

Ready-to-use Adenovirus expressing Mouse Ctnnb1 (catenin (cadherin associated protein), beta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Bfc; Catnb; Mesc

Description (Vector)

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.

Gene ID

12387

Gene Name (Vector)

catenin (cadherin associated protein), beta 1

Gene Symbol

Ctnnb1

ORF Size (aa)

2346

ORF Size (bp)

2346 bp

RefSeq ID

NM_007614

RefSeq Synonyms

NM_007614, NM_001165902, BC053065, BC048153,

Species

mouse

UniGene ID

Mm.291928

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.