human MYCN Adenovirus

Name 
Ad-h-MYCN
Cat No 
ADV-216142
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MYCN.

ADV-216142
Ad-h-MYCN

Ready-to-use Adenovirus expressing Human MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bHLHe37;class E basic helix-loop-helix protein 37;MODED;neuroblastoma MYC oncogene;neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene;NMYC;N-myc;N-myc proto-oncogene protein;ODED;oncogene NMYC;v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Description (eCommerce)
N-Myc is a member of the Myc family of proteins which include c-Myc, N-Myc, and L-Myc. Myc family members are transactivating DNA binding proteins with oncogenic potential. Transactivation by Myc requires dimerization with other basic helix-loop-helix transcription factors. N-myc dimerizes with the MAX transcription factor.
Description (Vector)
MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Gene ID
4613
Gene Name (eCommerce)
MYCN proto-oncogene, bHLH transcription factor
Gene Name (Vector)
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Gene Symbol
MYCN
HGNC ID
HGNC:7559
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1395
ORF Size (bp)
1395 bp
Protein Name (eCommerce)
N-myc proto-oncogene protein
RefSeq ID
NM_005378
RefSeq Synonyms
NM_005378, NM_001293233, NM_001293231, NM_001293228, BC002712,
Research Areas (Faceted)
cell_biology,immunology,transcription_translation,cancer
Species
human
UniGene ID
Hs.25960
UniProt ID (eCommerce)
P04198

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.