human MED18 Adenovirus

Name
Ad-h-MED18

Cat No
ADV-215247

Availability
4-5 weeks

This is an Adenovirus expressing Human MED18.

ADV-215247

Ad-h-MED18

Ready-to-use Adenovirus expressing Human MED18 (mediator complex subunit 18). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Mediator complex subunit 18; mediator of RNA polymerase II transcription subunit 18; mediator of RNA polymerase II transcription, subunit 18 homolog; p28b; SRB5; TRAP/mediator complex subunit p28b

Description (eCommerce)

MED18 is a component of the multisubunit mediator complex that functions as a bridge between gene-specific transcription factors and the RNA Pol II/general transcription factor machinery. The mediator complex was first identified as a coactivator of the thyroid hormone receptor and has since been observed to function as a coactivator of a variety of transcription factors. MED18 forms a subcomplex with the MED8 and MED20 subunits and plays an important role in initiation complex formation.

Description (Vector)

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

Gene ID

54797

Gene Name (eCommerce)

mediator complex subunit 18

Gene Name (Vector)

mediator complex subunit 18

Gene Symbol

MED18

HGNC ID

HGNC:25944

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

627

Protein Name (eCommerce)

Mediator of RNA polymerase II transcription subunit 18

RefSeq ID

NM_017638

RefSeq Synonyms

NM_017638, NM_001127350, BC002694,

Research Areas

Metabolism/Metabolic Process,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,metabolism,transcription_translation

Species

human

Target Sentence

MED18 is a component of the multisubunit mediator complex that functions as a bridge between gene-specific transcription factors and the RNA Pol II/general transcription factor machinery. The mediator complex was first identified as a coactivator of the thyroid hormone receptor and has since been observed to function as a coactivator of a variety of transcription factors. MED18 forms a subcomplex with the MED8 and MED20 subunits and plays an important role in initiation complex formation.

UniGene ID

Hs.479911

UniProt ID (eCommerce)

Q9BUE0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.